Document 0118
 DOCN  M9490118
 TI    Endothelin-1 immunoreactivity in plasma is elevated in HIV-1 infected
       patients with retinal microangiopathic syndrome.
 DT    9411
 AU    Rolinski B; Geier SA; Sadri I; Klauss V; Bogner JR; Ehrenreich H; Goebel
       FD; Medizinische Poliklinik, Ludwig-Maximilians-Universitat,; Munchen,
       Germany.
 SO    Clin Investig. 1994 Mar;72(4):288-93. Unique Identifier : AIDSLINE
       MED/94319112
 AB    Endothelin-1 is a recently identified cytokine with potent
       vasoconstrictor activity which is associated with various diseases
       involving blood vessels. HIV-1 related retinal microangiopathic syndrome
       is a frequent finding in patients with AIDS or AIDS-related complex,
       presenting predominantly with retinal cotton-wool spots. We investigated
       55 HIV-1 infected patients by ophthalmoscopy and for endothelin-1
       immunoreactivity in plasma and an additional 76 HIV-1 infected patients
       only for endothelin-1 levels. For reference values 13 age-matched
       healthy subjects were studied. In 18 of 55 patients (33%) investigated
       ophthalmoscopically we found evidence of microangiopathic syndrome.
       Overall, the mean endothelin-1 immunoreactivity in plasma of HIV-1
       infected patients was significantly elevated as compared to controls
       (4.28 +/- 3.62 versus 2.72 +/- 0.67 fmol/ml, P < 0.0001). HIV-1 infected
       patients with retinal microangiopathic syndrome had significantly higher
       plasma levels of endothelin-1 immunoreactivity (4.59 +/- 1.38 fmol/ml)
       compared to HIV-1 infected patients without microangiopathic syndrome
       (3.18 +/- 1.64 fmol/ml, P = 0.003). Correlation analysis revealed that
       endothelin-1 immunoreactivity in plasma had no significant association
       with disease progression, CD4 cell count, beta 2-microglobulin,
       neopterin, or age. Endothelin-1 immunoreactivity in plasma was
       correlated exclusively with retinal microangiopathic syndrome in one or
       both eyes (r = 0.45, P = 0.0006) and with the number of cotton-wool
       spots (r = 0.50, P = 0.0001). In conclusion, HIV-1 related retinal
       microangiopathic syndrome is associated with elevated plasma levels of
       endothelin-1. By virtue of its potent vasoconstrictor activity
       endothelin-1 may be involved in the pathogenesis of HIV-1 related
       vascular disease.
 DE    Adult  Endothelins/*BLOOD  Female  Human  HIV
       Infections/*BLOOD/COMPLICATIONS  *HIV-1  Male  Ophthalmoscopy  Retinal
       Diseases/BLOOD/MICROBIOLOGY/PATHOLOGY  Retinal Vessels/*PATHOLOGY
       Support, Non-U.S. Gov't  Syndrome  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).